BLM helicase complements disrupted type II telomere lengthening in telomerase-negative sgs1 yeast.

نویسندگان

  • Kate Lillard-Wetherell
  • Kelly A Combs
  • Joanna Groden
چکیده

Recombination-mediated pathways for telomere lengthening may be utilized in the absence of telomerase activity. The RecQ-like helicases, BLM and Sgs1, are implicated in recombination-mediated telomere lengthening in human cells and budding yeast, respectively. Here, we show that BLM expression rescues disrupted telomere lengthening in telomerase-negative sgs1 yeast. BLM helicase activity is required for this complementation, indicating BLM and Sgs1 resolve the same telomeric structures. These data support a conserved function for BLM and Sgs1 in recombination-mediated telomere lengthening.

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عنوان ژورنال:
  • Cancer research

دوره 65 13  شماره 

صفحات  -

تاریخ انتشار 2005